persistent hepatitis e virus genotype 4 infection in a child with acute lymphoblastic leukemia

نویسندگان

yansheng geng health science center, hebei university, baoding, china

hongxin zhang health science center, hebei university, baoding, china

weijin huang division of hiv/aids and sex-transmitted virus vaccines, national institutes for food and drug control, tiantanxili, beijing, china

tim j harrison division of medicine, university college london medical school, london, uk

چکیده

conclusions to our knowledge, this is the first chronic case confirmed by the prolonged presence of hev rna in china. it is also the first reported persistent hepatitis e infection caused by hev genotype 4. case presentation here we report a chinese boy with acute lymphoblastic leukemia, who developed hepatitis e during a period of intensive chemotherapy. twenty months after the initial infection, hev viremia was reappeared in the patient, with detectable anti-hev igm and igg and modestly elevated serum transaminases. sequence analysis of the viral rnas revealed the reactivation of the hev genotype 4d strain, indicating viral persistence in the patient. introduction in general, the hepatitis e virus (hev) causes acute, self-limiting hepatitis. prolonged and chronic infections caused by hev genotype 3 have been found in some immunosuppressed patients in developed countries.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Persistent Hepatitis E Virus Genotype 4 Infection in a Child With Acute Lymphoblastic Leukemia

INTRODUCTION In general, the hepatitis E virus (HEV) causes acute, self-limiting hepatitis. Prolonged and chronic infections caused by HEV genotype 3 have been found in some immunosuppressed patients in developed countries. CASE PRESENTATION Here we report a Chinese boy with acute lymphoblastic leukemia, who developed hepatitis E during a period of intensive chemotherapy. Twenty months after ...

متن کامل

Seroprevalence of Hepatitis E Virus Infection among Patients with Acute Hepatitis Symptoms in Ahvaz, Iran

Background and Aims: Hepatitis E virus (HEV) is considered as one of the common causes of acute viral hepatitis in the world, particularly in the developing countries. It also causes fulminant hepatitis in pregnant women. Although HEV infection in Iran is endemic, there are numerous reports of epidemics caused by this infection in this part of the world. This study aimed to determine seropreval...

متن کامل

Parvovirus infection in a child with acute lymphoblastic leukemia.

A6-year-old boy on maintenance treatment for acute lymphoblastic leukemia (according to mid-risk Protocol for ALL A.I.E.O.P. 9502) came to our observation because of anemia (Hb = 7 g/dL) and mild thrombocytopenia of no apparent etiology. A May-Grünwald-Giemsa stained blood smear revealed the presence of neutrophilia and rare immunocytes. Bone marrow smears showed maturation arrest of erythroid ...

متن کامل

Fatal Epstein-Barr virus infection in a child with acute lymphoblastic leukemia in remission.

A 9-year-old white boy developed a fatal primary Epstein-Barr virus (EBV) infection while receiving chemotherapy for acute lymphoblastic leukemia in remission. Histopathological findings at the height of the proliferative phase of the illness were compatible with a virally induced hemophagocytic syndrome. The infection spontaneously converted to complete aplasia of the bone marrow and lymph nod...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
hepatitis monthly

جلد ۱۴، شماره ۱، صفحات ۰-۰

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023